Prucalopride

• CAT Number: A000859
• CAS Number: 179474-81-8
• Molecular Formula: C18H26ClN3O3
• Molecular Weight: 367.87
• Purity: 98%
• Synonyms: 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
• Target: HTR4
• Target Protein: Q13639
• Solubility: Soluble in DMSO > 10 mM
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IC50: 5-HT4A Receptor:8.6 (pKi) 5-HT4B Receptor:8.1 (pKi)
• IUPAC Name: 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
• InChI: InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
• InChIKey: ZPMNHBXQOOVQJL-UHFFFAOYSA-N
• SMILES: COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl

Prucalopride（Cat No.:A000859）is a selective serotonin 5-HT4 receptor agonist used to treat chronic constipation. By stimulating 5-HT4 receptors in the gastrointestinal tract, it enhances bowel motility and accelerates colonic transit, providing relief from constipation symptoms. Prucalopride’s targeted action ensures effectiveness with a favorable safety profile, minimizing the risk of cardiovascular side effects associated with earlier prokinetic agents. It is especially beneficial for patients unresponsive to traditional laxatives, improving quality of life and gastrointestinal health. Prucalopride represents a significant advancement in the management of chronic constipation.