Prucalopride hydrochloride

• CAT Number: I035110
• CAS Number: 179474-80-7
• Molecular Formula: C18H27Cl2N3O3
• Molecular Weight: 404.33
• Purity: 98%
• Synonyms: R-108512; R 108512; R108512; R 093877; R-093877; R093877; R 93877; R-93877; R93877; Prucalopride hydrochloride; Prucalopride HCl; Motegrity; Resolor; Resotran
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide hydrochloride
• InChI: InChI=1S/C18H26ClN3O3.ClH/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;/h11-12H,2-10,20H2,1H3,(H,21,23);1H
• InChIKey: KKMOQGWTJRGLNN-UHFFFAOYSA-N
• SMILES: COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.Cl

Prucalopride Hydrochloride(CAT: I035110) is a highly selective serotonin 5-HT₄ receptor agonist used primarily in gastrointestinal research to study treatments for chronic idiopathic constipation (CIC). By stimulating 5-HT₄ receptors in the enteric nervous system, it enhances colonic motility and accelerates bowel movements without significantly affecting other serotonin receptors, minimizing cardiovascular side effects. Prucalopride Hydrochloride is valuable in exploring therapies for gastrointestinal motility disorders and irritable bowel syndrome (IBS). Its mechanism of action provides insights into developing safe and effective treatments for improving gut motility and managing chronic constipation in patients unresponsive to traditional laxatives.