For research use only. Not for therapeutic Use.
Prucalopride Succinate (Cat No.: I008890) is a selective, high-affinity 5-HT₄ receptor agonist used to stimulate gastrointestinal motility. It enhances colonic peristalsis, promoting bowel movements and is primarily indicated for the treatment of chronic idiopathic constipation. Unlike older prokinetic agents, Prucalopride shows minimal affinity for other serotonin receptor subtypes, reducing the risk of cardiovascular side effects. It has also been explored for potential benefits in gastrointestinal disorders such as gastroparesis. Prucalopride Succinate is valuable in both clinical and pharmacological research on gut motility.
| CAS Number | 179474-85-2 (Succinate); 179474-81-8 (free base). |
| Synonyms | R-108512; R 108512; R108512; Prucalopride Succinate; Resolor; Resotran.;4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate |
| Molecular Formula | C22H32ClN3O7 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acid |
| InChI | 1S/C18H26ClN3O3.C4H6O4/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;5-3(6)1-2-4(7)8/h11-12H,2-10,20H2,1H3,(H,21,23);1-2H2,(H,5,6)(H,7,8) |
| InChIKey | QZRSNVSQLGRAID-UHFFFAOYSA-N |
| SMILES | COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O |
| Reference | </br>1:Selective separation and characterisation of stress degradation products and process impurities of prucalopride succinate by LC-QTOF-MS/MS. Mahamuni BS, Jajula A, Awasthi A, Kalariya PD, Talluri MV.J Pharm Biomed Anal. 2016 Jun 5;125:219-28. doi: 10.1016/j.jpba.2016.03.047. Epub 2016 Mar 24. PMID: 27037978 </br>2:Prucalopride succinate for the treatment of constipation: an update. Bassotti G, Gambaccini D, Bellini M.Expert Rev Gastroenterol Hepatol. 2016;10(3):291-300. doi: 10.1586/17474124.2016.1129897. Epub 2016 Jan 29. Review. PMID: 26647167 |
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