For research use only. Not for therapeutic Use.
PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48[1][2].
PS47 shows very low binding affinity or no binding to PDK1 (Kd>200 µM)[1].
| Catalog Number | I035117 |
| CAS Number | 1180676-33-8 |
| Synonyms | (E)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid |
| Molecular Formula | C17H15ClO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12+ |
| InChIKey | LLJYFDRQFPQGNY-NTCAYCPXSA-N |
| SMILES | C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl |
| Reference | [1]. Hindie V, et, al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64. [2]. Pastor-Flores D, et, al. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 2013 Oct 18;8(10):2283-92. |
