PSB-18484

For research use only. Not for therapeutic Use.

  • CAT Number: I035140
  • Molecular Formula: C12H9FINO4
  • Molecular Weight: 377.1099
  • Purity: 98%
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PSB-18484 is a Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 (EC50 = 32.1 nM).


Catalog Number I035140
Synonyms

PSB-18484; PSB 18484; PSB18484.

Molecular Formula C12H9FINO4
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 3-(2-Carboxyethyl)-4-fluoro-6-iodo-1H-indole-2-carboxylic Acid
InChI InChI=1S/C12H9FINO4/c13-7-3-5(14)4-8-10(7)6(1-2-9(16)17)11(15-8)12(18)19/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
InChIKey DDCPVTXQTABQGM-UHFFFAOYSA-N
SMILES O=C(C(N1)=C(CCC(O)=O)C2=C1C=C(I)C=C2F)O
Reference

1: Baqi Y, Pillaiyar T, Abdelrahman A, Kaufmann O, Alshaibani S, Rafehi M,
Ghasimi S, Akkari R, Ritter K, Simon K, Spinrath A, Kostenis E, Zhao Q, Köse M,
Namasivayam V, Müller CE. 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives:
Structural Requirements and Properties of Potent Agonists of the Orphan G
Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 5. doi:
10.1021/acs.jmedchem.7b01768. [Epub ahead of print] PubMed PMID: 30048589.

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