PSB-18484

• CAT Number: I035140
• Molecular Formula: C12H9FINO4
• Molecular Weight: 377.11
• Purity: 98%
• Synonyms: PSB-18484; PSB 18484; PSB18484.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-(2-carboxyethyl)-4-fluoro-6-iodo-1H-indole-2-carboxylic acid
• InChI: InChI=1S/C12H9FINO4/c13-7-3-5(14)4-8-10(7)6(1-2-9(16)17)11(15-8)12(18)19/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
• InChIKey: DDCPVTXQTABQGM-UHFFFAOYSA-N
• SMILES: C1=C(C=C(C2=C1NC(=C2CCC(=O)O)C(=O)O)F)I

PSB-18484（Cat No.:I035140）is a selective small molecule inhibitor of the enzyme soluble epoxide hydrolase (sEH). By inhibiting sEH, PSB-18484 enhances the activity of epoxyeicosatrienoic acids (EETs), which play a role in regulating blood pressure, inflammation, and vascular function. It has potential therapeutic applications in conditions like hypertension, cardiovascular diseases, and inflammation-related disorders. Preclinical studies suggest that PSB-18484 may help improve endothelial function and reduce vascular inflammation. However, further clinical research is needed to determine its efficacy and safety in humans before widespread medical use.