For research use only. Not for therapeutic Use.
PSB-KD107 is a selective, non-lipid-like agonist for GPR18 with an EC50 value of 0.562 μM for human GPR18. Moreover, PSB-KD107 was more potent and much more efficacious than the standard GPR18 agonist THC. PSB-KD107 had also been identified as a moderately potent antagonist for the human adenosine A2A receptor with a Ki value of 4.56 μM.
KEYWORDS: PSB-KD107 | Supplier | GPR18 agonist | PSB KD107 | PSBKD107 | CAS [955121-65-0] | Non Selective | GPR18 | Agonist | Receptors | Tetrahydrocannabinol | THC
| Catalog Number | I035146 |
| CAS Number | 955121-65-0 |
| Molecular Formula | C20H22N6O2 |
| Purity | ≥95% |
| IUPAC Name | 9-[2-(1H-indol-3-yl)ethyl]-1,3-dimethyl-6,7,8,9a,10,10a-hexahydro-4aH-purino[7,8-a]pyrimidine-2,4-dione |
| InChI | InChI=1S/C20H26N6O2/c1-23-17-16(18(27)24(2)20(23)28)26-10-5-9-25(19(26)22-17)11-8-13-12-21-15-7-4-3-6-14(13)15/h3-4,6-7,12,16-17,19,21-22H,5,8-11H2,1-2H3 |
| SMILES | CN1C2C(C(=O)N(C1=O)C)N3CCCN(C3N2)CCC4=CNC5=CC=CC=C54 |
| Reference | A Drabczyńska et al. Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands. Bioorg Med Chem. 2007 Nov 15;15(22):6956-74. CT Schoeder et al. Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. ACS Med Chem Lett. 2020 Jun 17;11(10):2024-2031. |
