Pseudouridimycin

• CAT Number: I017958
• CAS Number: 1566586-52-4
• Molecular Formula: C₁₇H₂₆N₈O₉
• Molecular Weight: 486.44
• Purity: ≥95%
• Target: Anti-infection
• Storage: Store at -20°C
• IUPAC Name: (2S)-2-[[2-(diaminomethylideneamino)acetyl]-hydroxyamino]-N-[[(2R,3S,4R,5S)-5-(2,4-dioxo-1H-pyrimidin-5-yl)-3,4-dihydroxyoxolan-2-yl]methyl]pentanediamide
• InChI: InChI=1S/C17H26N8O9/c18-9(26)2-1-7(25(33)10(27)5-22-16(19)20)15(31)21-4-8-11(28)12(29)13(34-8)6-3-23-17(32)24-14(6)30/h3,7-8,11-13,28-29,33H,1-2,4-5H2,(H2,18,26)(H,21,31)(H4,19,20,22)(H2,23,24,30,32)/t7-,8+,11+,12+,13-/m0/s1
• InChIKey: XDEYHXABZOKKDZ-YFKLLHAASA-N
• SMILES: C1=C(C(=O)NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CNC(=O)[C@H](CCC(=O)N)N(C(=O)CN=C(N)N)O)O)O

Pseudouridimycin（Cat No.:I017958）is a natural product and a potent inhibitor of bacterial RNA polymerase. It functions by targeting the enzyme’s active site, specifically binding to the RNA polymerase and preventing the transcription process in bacteria. Pseudouridimycin is derived from the actinomycete Streptomyces species and exhibits broad-spectrum antibacterial activity, including against drug-resistant strains. It is structurally similar to other antibiotics but has unique features, making it a promising candidate for further development as a novel antimicrobial agent. Researchers are exploring its potential in treating bacterial infections, particularly those resistant to existing antibiotics.

Reference

[1]. Rosenqvist P, et al. Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin. Sci Rep. 2019 Jun 20;9(1):8935.