For research use only. Not for therapeutic Use.
PSI-7409（Cat No.:I013531）is the active diastereomer of Sofosbuvir, a nucleotide analog prodrug used in the treatment of hepatitis C virus (HCV) infections. As a potent NS5B RNA polymerase inhibitor, it incorporates into viral RNA, causing chain termination and halting replication. PSI-7409 exhibits high selectivity and efficacy against multiple HCV genotypes, making it a valuable compound in antiviral research. Its role in the development of direct-acting antivirals (DAAs) underscores its importance in studying viral replication mechanisms and advancing therapeutic strategies for managing chronic HCV infections.
| Catalog Number | I013531 |
| CAS Number | 1015073-42-3 |
| Molecular Formula | C₁₀H₁₆FN₂O₁₄P₃ |
| Purity | ≥95% |
| Target | HCV |
| Solubility | DMSO |
| Storage | Store at -20°C |
| IUPAC Name | [[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| InChI | InChI=1S/C10H16FN2O14P3/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1 |
| InChIKey | IPHULAIUXUVCHH-VPCXQMTMSA-N |
| SMILES | C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F |
| Reference | [1]. Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2//’-deoxy-2//’-fluoro-2//’-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96.<br>[2]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. |
