For research use only. Not for therapeutic Use.
PSI-7409 Tetrasodium（Cat No.:I020251）is a potent, selective inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, used in research related to cystic fibrosis and other pulmonary disorders. By targeting the CFTR protein, PSI-7409 Tetrasodium helps modulate chloride ion transport across epithelial membranes, which is critical in regulating airway hydration and mucociliary clearance. It holds potential for therapeutic development in restoring defective ion transport in cystic fibrosis patients, improving lung function, and offering a novel approach to treating CFTR-related diseases. This compound is valuable in advanced pharmaceutical and biochemical research.
| Catalog Number | I020251 |
| CAS Number | 1621884-22-7 |
| Molecular Formula | C₁₀H₁₂FN₂Na₄O₁₄P₃ |
| Purity | ≥95% |
| Target | HCV |
| Storage | Store at -20°C |
| IUPAC Name | tetrasodium;[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate |
| InChI | InChI=1S/C10H16FN2O14P3.4Na/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19;;;;/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19);;;;/q;4*+1/p-4/t5-,7-,8-,10-;;;;/m1..../s1 |
| InChIKey | MEVRFPOAFPAGDY-DLULJLDFSA-J |
| SMILES | C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)F.[Na+].[Na+].[Na+].[Na+] |
| Reference | [1]. Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2′-deoxy-2′-fluoro-2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96.<br>[2]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47. |
