For research use only. Not for therapeutic Use.
PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2].
The endogenous ligand OEA signals through GPR119 in a manner similar to glucagon-like peptide-1 (GLP-1) and its receptor with respect to insulin secretion, intracellular calcium and cAMP[2].
| Catalog Number | I008902 |
| CAS Number | 388575-52-8 |
| Synonyms | 5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole |
| Molecular Formula | C17H23N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3 |
| InChIKey | OAVLEYPTWABFLF-UHFFFAOYSA-N |
| SMILES | CCCCC1CCC(CC1)C2=NC(=NO2)C3=CC=NC=C3 |
| Reference | [1]. Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. [2]. Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065. |
