Psoralen

• CAT Number: I004520
• CAS Number: 66-97-7
• Molecular Formula: C11H6O3
• Molecular Weight: 186.2
• Purity: ≥95%
• Synonyms: Ficusin;Furocoumarin;NSC 404562
• Solubility: DMSO: ≥ 1.9 mg/mL
• Storage: 2-8°C
• IUPAC Name: furo[3,2-g]chromen-7-one
• InChI: InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
• InChIKey: ZCCUUQDIBDJBTK-UHFFFAOYSA-N
• SMILES: C1=CC(=O)OC2=CC3=C(C=CO3)C=C21

Psoralen (Cat No.: I004520) is a compound known for its ability to enhance melanin production in the skin. When exposed to ultraviolet light, it can induce a phototoxic reaction and selectively impede DNA synthesis in epidermal cells. Psoralen also demonstrates substantial inhibitory effects on various cancer cell lines, including S180, Ehrlich ascites carcinoma, and liver cancer H-22. This dual action, both in enhancing pigmentation and inhibiting cancer cell growth, underscores its versatility and potential applications in dermatology and oncology.

Reference

[1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6.
[2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7.
[3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10.