For research use only. Not for therapeutic Use.
PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers[1].
| Catalog Number | I010882 |
| CAS Number | 331002-70-1 |
| Synonyms | 2-chloro-5-[[(5E)-5-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]benzoic acid |
| Molecular Formula | C23H16ClN3O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10+ |
| InChIKey | RTHRCOIONCZINZ-KEBDBYFISA-N |
| SMILES | CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)C=C3C(=O)NC(=NC4=CC(=C(C=C4)Cl)C(=O)O)S3 |
| Reference | [1]. Pang T, et al. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J Biol Chem. 2008 Jun 6;283(23):16051-60. |
