PTC-028

For research use only, not for therapeutic use.

  • CAT Number: I014656
  • CAS Number: 1782970-28-8
  • Molecular Formula: C19H12F5N5
  • Molecular Weight: 405.332
  • Purity: ≥95%
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PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification. In vivo, orally administered PTC-028, as a single agent, exhibits significant antitumor activity comparable with the standard cisplatin/paclitaxel therapy in an orthotopic mouse model of ovarian cancer.


Catalog Number I014656
CAS Number 1782970-28-8
Synonyms

PTC-028; PTC028; PTC 028;2-Pyrazinamine, 6-(5,6-difluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]-

Molecular Formula C19H12F5N5
Purity ≥95%
Solubility Soluble in DMSO
InChI InChI=1S/C19H12F5N5/c1-10-26-15-6-13(20)14(21)7-16(15)29(10)18-9-25-8-17(28-18)27-12-4-2-11(3-5-12)19(22,23)24/h2-9H,1H3,(H,27,28)
InChIKey JEZGPBWIZWPDHP-UHFFFAOYSA-N
SMILES FC(C1=CC=C(NC2=NC(N3C4=CC(F)=C(F)C=C4N=C3C)=CN=C2)C=C1)(F)F
Reference

</br>Dey A, et al. Mol Cancer Ther. 2018, 17(1):39-49. </br>

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