For research use only. Not for therapeutic Use.
PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].
PTP Inhibitor IV down-regulates the catalytic activity of DUSP14 by binding in the catalytic site[1].
PTP Inhibitor IV (0-100 μM; 3 hours) effectively and specifically inhibits DUSP14-mediated dephosphorylation of JNK[1].
| Catalog Number | I011771 |
| CAS Number | 329317-98-8 |
| Synonyms | 1,1,1-trifluoro-N-[4-[2-[4-[2-[4-(trifluoromethylsulfonylamino)phenyl]propan-2-yl]phenyl]propan-2-yl]phenyl]methanesulfonamide |
| Molecular Formula | C26H26F6N2O4S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H26F6N2O4S2/c1-23(2,19-9-13-21(14-10-19)33-39(35,36)25(27,28)29)17-5-7-18(8-6-17)24(3,4)20-11-15-22(16-12-20)34-40(37,38)26(30,31)32/h5-16,33-34H,1-4H3 |
| InChIKey | JWNAVYMNAQDLHX-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)NS(=O)(=O)C(F)(F)F)C3=CC=C(C=C3)NS(=O)(=O)C(F)(F)F |
| Reference | [1]. Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9. [2]. Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11(8):1835-49. |
