PTP1B-IN-1

• CAT Number: I004308
• CAS Number: 612530-44-6
• Molecular Formula: C8H8N2O3S
• Molecular Weight: 212.223
• Purity: ≥95%
• Synonyms: 1,1-dioxo-5-phenyl-1,2,5-thiadiazolidin-3-one
• Target: Phosphatase
• Solubility: DMSO: ≥ 38 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C8H8N2O3S/c11-8-6-10(14(12,13)9-8)7-4-2-1-3-5-7/h1-5H,6H2,(H,9,11)
• InChIKey: LDCZCUKQWRZSDT-UHFFFAOYSA-N
• SMILES: C1C(=O)NS(=O)(=O)N1C2=CC=CC=C2

PTP1B-IN-1 (CAT: I004308) is a potent inhibitor of the protein tyrosine phosphatase-1B (PTP1B) with an IC50 of 1.6 mM. It features a 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold, which serves as a core structure for the synthesis of derivatives. By targeting PTP1B, an enzyme involved in the regulation of insulin signaling and other cellular processes, PTP1B-IN-1 has the potential to modulate important signaling pathways and contribute to the development of novel therapeutic interventions for conditions such as diabetes and metabolic disorders.

Reference

[1]. Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.
[2]. Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.