PTP1B-IN-22

• CAT Number: I041719
• CAS Number: 86109-60-6
• Molecular Formula: C16H12N2O3S2
• Molecular Weight: 344.41
• Purity: ≥95%
• Synonyms: 4-[[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]amino]benzoic acid
• InChI: InChI=1S/C16H12N2O3S2/c19-14(17-11-7-5-10(6-8-11)15(20)21)9-22-16-18-12-3-1-2-4-13(12)23-16/h1-8H,9H2,(H,17,19)(H,20,21)
• InChIKey: ARVQDURBWHSEPA-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N=C(S2)SCC(=O)NC3=CC=C(C=C3)C(=O)O

PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes[1].
PTP1B-IN-22 (compound 3j; myotubes) shows 66.4 % in vitro PTP1B inhibition and 39.6 % increase in glucose uptake[1].

Reference

[1]. Prashant J, et, al. Molecular modeling and synthesis of ZINC02765569 derivatives as protein tyrosine phosphatase 1B inhibitors: lead optimization study. 2012;22: 1618-23.