PTP1B-IN-9

• CAT Number: I016708
• CAS Number: 145888-79-5
• Molecular Formula: C₁₉H₁₃Cl₄NO
• Molecular Weight: 413.12
• Purity: ≥95%
• IUPAC Name: (3E,5E)-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one
• InChI: InChI=1S/C19H13Cl4NO/c20-15-3-1-11(7-17(15)22)5-13-9-24-10-14(19(13)25)6-12-2-4-16(21)18(23)8-12/h1-8,24H,9-10H2/b13-5+,14-6+
• InChIKey: GJPXGFGIFQWUOC-ACFHMISVSA-N
• SMILES: C\1NC/C(=C\C2=CC(=C(C=C2)Cl)Cl)/C(=O)/C1=C/C3=CC(=C(C=C3)Cl)Cl

PTP1B-IN-9(Cat Np.:I016708) is a ubiquitin-proteasome system (UPS)-a stressor that inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activities. This leads to a UPS-stress response without affecting 20S proteasome catalytic activities. PTP1B-IN-9 has shown anticancer activity by reducing the viability of HPV16-positive SiHa and Caski cells as well as HPV-39-positive ME180 cervical cancer cell lines in a dose-dependent manner. It also reduces the cell viability of HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM.

Reference

[1]. Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.