PTZ-343

• CAT Number: I008910
• CAS Number: 101199-38-6
• Molecular Formula: C15H14NNaO3S2
• Molecular Weight: 343.391
• Purity: ≥95%
• Synonyms: sodium 3-(10H-phenothiazin-10-yl)propane-1-sulfonate; SODIUM PHENOTHIAZINE-10-YL-PROPYLSULFONATE; 10H-Phenothiazine-10-propanesulfonic acid sodium salt
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• Related CAS: 129808-92-0 (free acid form)
• IUPAC Name: sodium;3-phenothiazin-10-ylpropane-1-sulfonate
• InChI: InChI=1S/C15H15NO3S2.Na/c17-21(18,19)11-5-10-16-12-6-1-3-8-14(12)20-15-9-4-2-7-13(15)16;/h1-4,6-9H,5,10-11H2,(H,17,18,19);/q;+1/p-1
• InChIKey: VKGYKXFNSKEHED-UHFFFAOYSA-M
• SMILES: C1=CC=C2C(=C1)N(C3=CC=CC=C3S2)CCCS(=O)(=O)[O-].[Na+]

PTZ-343 (CAT: I008910), also known as sodium 3-(10H-phenothiazin-10-yl)propane-1-sulfonate, is a phenothiazine derivative with a molecular weight of 343. It acts as an electron transfer mediator and exhibits unique properties in chemiluminescence reactions. In the presence of horseradish peroxidase isozyme II (HRP-II), PTZ-343 reacts with it, resulting in the release of HRP and a PTZ-343 radical. This PTZ-343 radical serves as an oxidizing agent for luminol anions, leading to the induction of light emission or chemiluminescence. Notably, PTZ-343 significantly enhances HRP-induced chemiluminescent light emission by over 800%. Furthermore, it has the ability to enhance soybean peroxidase-induced chemiluminescence, thereby improving sensitivity and lowering the detection limit.

Reference

1. Masato. Sakaguchi , Ming. Hu , Larry. Kevan. Photoionization of alkylphenothiazines in vesicles: effects of the alkyl chain length and the vesicle surface charge. J. Phys. Chem., 1990, 94 (2), pp 870–874.

2.Vdovenko, M.M., Della Ciana, L., and Sakharov, I.Y. 3-<wbr style=”box-sizing: border-box;” />(100-<wbr style=”box-sizing: border-box;” />Phenothiazinyl)propane-<wbr style=”box-sizing: border-box;” />1-<wbr style=”box-sizing: border-box;” />sulfonate is a potent enhancer of soybean peroxidase-<wbr style=”box-sizing: border-box;” />induced chemiluminescence. Anal. Biochem. 392(1), 54-58 (2009).