PU-48

• CAT Number: I040883
• CAS Number: 335394-78-0
• Molecular Formula: C14H12N2O3S
• Molecular Weight: 288.32
• Purity: ≥95%
• Synonyms: methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate
• InChI: InChI=1S/C14H12N2O3S/c1-18-8-3-4-10-7(5-8)6-9-11(15)12(14(17)19-2)20-13(9)16-10/h3-6H,15H2,1-2H3
• InChIKey: XRJKHUHLPVGTCL-UHFFFAOYSA-N
• SMILES: COC1=CC2=CC3=C(N=C2C=C1)SC(=C3N)C(=O)OC

PU-48(CAT: I040883) is a potent inhibitor of urea transporters A (UT-A), with an IC50 of 0.32 μM. It exhibits a strong diuretic effect in mouse models while showing minimal or no cytotoxicity. By inhibiting UT-A, PU-48 disrupts urea reabsorption in the kidneys, promoting increased urine output. This compound holds potential for development as a diuretic agent, which could be useful for managing conditions like edema and congestive heart failure, where fluid retention is a major concern. Its low toxicity profile further supports its promise in therapeutic applications.