For research use only. Not for therapeutic Use.
PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic[1].
| Catalog Number | I040883 |
| CAS Number | 335394-78-0 |
| Synonyms | methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate |
| Molecular Formula | C14H12N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C14H12N2O3S/c1-18-8-3-4-10-7(5-8)6-9-11(15)12(14(17)19-2)20-13(9)16-10/h3-6H,15H2,1-2H3 |
| InChIKey | XRJKHUHLPVGTCL-UHFFFAOYSA-N |
| SMILES | COC1=CC2=CC3=C(N=C2C=C1)SC(=C3N)C(=O)OC |
| Reference | [1]. Ren H, et al. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72. |
