For research use only. Not for therapeutic Use.
Potent inhibitor of heat shock protein 90 (Hsp90) with IC50 of 51 nM; inhibits cell growth in a range of breast cancer cell lines; inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
Note: On the developers request, this product is not for sale for our customers in the United States.
| Catalog Number | I047570 |
| CAS Number | 2108826-10-2 |
| Molecular Formula | C18H21IN6O2S.3HCl |
| Purity | ≥95% |
| IUPAC Name | 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[3-(propan-2-ylamino)propyl]purin-6-amine;trihydrochloride |
| InChI | InChI=1S/C18H21IN6O2S.3ClH/c1-10(2)21-4-3-5-25-17-15(16(20)22-8-23-17)24-18(25)28-14-7-13-12(6-11(14)19)26-9-27-13;;;/h6-8,10,21H,3-5,9H2,1-2H3,(H2,20,22,23);3*1H |
| SMILES | CC(C)NCCCN1C2=NC=NC(=C2N=C1SC3=C(C=C4C(=C3)OCO4)I)N.Cl.Cl.Cl |
| Reference | SK Moulick et al. Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chem. Biol. 2011, 7, 818–826.
E Caldas-Lopes et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc. Natl. Acad. Sci. USA 2009, 106, 8368.
H He et al. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J. Med. Chem. 2006, 49(1), 381-90. |
