PU139

• CAT Number: I035197
• CAS Number: 158093-65-3
• Molecular Formula: C12H7FN2OS
• Molecular Weight: 246.26
• Purity: 98%
• Synonyms: PU139; PU-139; PU 139
• Target: Histone Acetyltransferase
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
• InChI: InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
• InChIKey: QMCIVCACYJRAAY-UHFFFAOYSA-N
• SMILES: O=C1N(C2=CC=C(F)C=C2)SC3=NC=CC=C31

PU139(CAT: I035197) is a novel inhibitor of histone acetyltransferase (HAT), targeting epigenetic regulation by suppressing histone acetylation. By inhibiting HAT activity, PU139 interferes with chromatin remodeling and transcriptional activation, making it a valuable tool for studying gene expression modulation. This mechanism has significant implications in oncology research, where aberrant histone acetylation is associated with tumor progression and drug resistance. PU139 is particularly suited for exploring epigenetic therapies and investigating the role of HATs in cancer and other diseases, providing researchers with a precise approach to advance epigenetic-focused pharmacology.