PU139

• CAT Number: I035197
• CAS Number: 158093-65-3
• Molecular Formula: C12H7FN2OS
• Molecular Weight: 246.2594
• Purity: 98%
• Synonyms: PU139; PU-139; PU 139
• Target: Histone Acetyltransferase
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
• InChI: InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
• InChIKey: QMCIVCACYJRAAY-UHFFFAOYSA-N
• SMILES: O=C1N(C2=CC=C(F)C=C2)SC3=NC=CC=C31

PU139 is a novel histone acetyltransferase (HAT) inhibitor.

Reference

1: Gajer JM, Furdas SD, Gründer A, Gothwal M, Heinicke U, Keller K, Colland F, Fulda S, Pahl HL, Fichtner I, Sippl W, Jung M. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015 Feb 9;4:e137. doi: 10.1038/oncsis.2014.51. PubMed PMID: 25664930; PubMed Central PMCID: PMC4338425.
2: Carneiro VC, de Abreu da Silva IC, Torres EJ, Caby S, Lancelot J, Vanderstraete M, Furdas SD, Jung M, Pierce RJ, Fantappié MR. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014 May 8;10(5):e1004116. doi: 10.1371/journal.ppat.1004116. eCollection 2014 May. PubMed PMID: 24809504; PubMed Central PMCID: PMC4014452.