Pulsatilla saponin D

• CAT Number: I004555
• CAS Number: 68027-15-6
• Molecular Formula: C47H76O17
• Molecular Weight: 913.1
• Purity: ≥95%
• Target: Apoptosis
• Solubility: DMSO: 40 mg/mL
• Storage: 3 years -20C powder

Pulsatilla saponin D (CAT: I004555), isolated from the root of Pulsatilla koreana, has shown potential as a chemopreventive agent for cancer. It effectively inhibits the growth of gastric cancer cells and pancreatic cancer cells, inducing apoptosis through mechanisms such as caspase activation and mitochondrial membrane potential disruption. SB365 also exhibits anti-angiogenic activity by reducing the expression of HIF-1α and VEGF. In gastric cancer cells, it specifically inhibits the activated form of c-Met, a receptor tyrosine kinase associated with cancer progression. In in vivo studies, SB365 demonstrates strong anticancer activity by inhibiting tumor growth, inducing apoptosis, and inhibiting angiogenesis, surpassing the effectiveness of the chemotherapy drug 5-FU. These findings suggest that Pulsatilla saponin D has the potential as a therapeutic agent for various types of cancer.

Reference

[1]. Hong SW, et al. SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities. Carcinogenesis. 2013 Sep;34(9):2156-69.

[2]. Son MK, et al. SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. Oncol Rep. 2013 Aug;30(2):801-8.

[3]. Son MK, et al. SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. Food Chem. 2013 Jan 1;136(1):26-33.