Pumafentrine

• CAT Number: I035211
• CAS Number: 207993-12-2
• Molecular Formula: C29H39N3O3
• Molecular Weight: 477.64
• Purity: 98%
• Synonyms: Pumafentrine; BY343; BYK 33043; BY-343; BYK33043
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-((4aR,10bS)-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)-N,N-diisopropylbenzamide
• InChI: InChI=1S/C29H39N3O3/c1-8-35-27-15-22-23(16-26(27)34-7)28(30-25-13-14-31(6)17-24(22)25)20-9-11-21(12-10-20)29(33)32(18(2)3)19(4)5/h9-12,15-16,18-19,24-25H,8,13-14,17H2,1-7H3/t24-,25-/m1/s1
• InChIKey: CVDXFPBVOIERBH-JWQCQUIFSA-N
• SMILES: O=C(N(C(C)C)C(C)C)C1=CC=C(C2=N[C@]3([H])CCN(C)C[C@]3([H])C4=CC(OCC)=C(OC)C=C24)C=C1

Pumafentrine is a dual inhibitor of PDE3 and PDE4.

Reference

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3: Dony E, Lai YJ, Dumitrascu R, Pullamsetti SS, Savai R, Ghofrani HA, Weissmann N, Schudt C, Flockerzi D, Seeger W, Grimminger F, Schermuly RT. Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition. Eur Respir J. 2008 Mar;31(3):599-610. Epub 2007 Nov 21. PubMed PMID: 18032446.