For research use only. Not for therapeutic Use.
PUN30119 (Cat.No:I035217), also known as Imidazole ketone erastin (IKE), is an effective, metabolically stable, and selective inhibitor of system xc^−, as well as an inducer of ferroptosis. It targets the system xc^− transporter, blocking the exchange of cystine and glutamate, leading to depletion of intracellular glutathione and inducing iron-dependent oxidative cell death (ferroptosis). IKE has shown potential anti-tumor activity in cancer therapy research, offering possibilities for novel treatment approaches.
| Catalog Number | I035217 |
| CAS Number | 1801530-11-9 |
| Synonyms | PUN30119; PUN-30119; PUN 30119; |
| Molecular Formula | C35H35ClN6O5 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 3-(5-(2-(1H-imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one |
| InChI | InChI=1S/C35H35ClN6O5/c1-24(2)47-32-12-7-25(31(43)20-40-14-13-37-23-40)19-30(32)42-33(38-29-6-4-3-5-28(29)35(42)45)21-39-15-17-41(18-16-39)34(44)22-46-27-10-8-26(36)9-11-27/h3-14,19,23-24H,15-18,20-22H2,1-2H3 |
| InChIKey | PSPXJPWGVFNGQI-UHFFFAOYSA-N |
| SMILES | O=C1N(C2=CC(C(CN3C=NC=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=C1C=CC=C6 |
| Reference | 1. Zhang Y, et al. Cell Chem Biol. 2019 Jan 31. pii: S2451-9456(19)30030-3. |
