For research use only. Not for therapeutic Use.
Puromycin-d3 dihydrochloride, a premium pharmaceutical research compound designed for advanced studies in protein synthesis and molecular biology. As a deuterated analog of Puromycin dihydrochloride, it offers enhanced stability and improved isotopic tracking. Puromycin-d3 dihydrochloride is ideal for use in pharmacological, biochemical, and genetic research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel therapies and research in protein synthesis inhibition. Trusted by leading laboratories, Puromycin-d3 dihydrochloride is your go-to solution for cutting-edge molecular biology research. Unlock new possibilities in protein synthesis studies with Puromycin-d3 dihydrochloride, where innovation meets reliability.
| Catalog Number | S000195 |
| Molecular Formula | C22H28D3Cl2N7O5 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-[4-(trideuteriomethoxy)phenyl]propanamide;dihydrochloride |
| InChI | InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1/i3D3;; |
| InChIKey | MKSVFGKWZLUTTO-WRRRLKTQSA-N |
| SMILES | [2H]C([2H])([2H])OC1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H]2[C@H](O[C@H]([C@@H]2O)N3C=NC4=C3N=CN=C4N(C)C)CO)N.Cl.Cl |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Nathans D, et al. Puromycin inhibition of protein synthesis: incorporation of puromycin intopeptide chains. Proc Natl Acad Sci U S A. 1964 Apr;51:585-92. [3]. Miyamoto-Sato E, et al. Specific bonding of puromycin to full-length protein at the C-terminus. Nucleic Acids Res. 2000 Mar 1;28(5):1176-82. [4]. Schmidt EK, et al. SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods. 2009 Apr;6(4):275-7. |
