For research use only. Not for therapeutic Use.
Purvalanol B（Cat No.:I002640）is a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK2 and CDK4, which play crucial roles in cell cycle regulation. By inhibiting these kinases, Purvalanol B induces cell cycle arrest at the G1 and G2 phases, preventing cell proliferation. This compound has been extensively studied for its anti-cancer potential, showing efficacy in promoting apoptosis in various cancer cell lines, including breast and prostate cancers. Purvalanol B is also used as a research tool to study cell cycle mechanisms, CDK-related pathways, and potential therapeutic applications in oncology.
| Catalog Number | I002640 |
| CAS Number | 212844-54-7 |
| Synonyms | 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid |
| Molecular Formula | C20H25ClN6O3 |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | DMSO: ≥ 40 mg/mL |
| Storage | Store at +4°C |
| IC50 | 6 nM(cdc2/cyclin B); 6 nM(cdk2/cyclin A); 9 nM(cdk2/cyclin E); 6 nM(cdk5-p35)[1] |
| IUPAC Name | 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid |
| InChI | InChI=1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1 |
| InChIKey | ZKDXRFMOHZVXSG-HNNXBMFYSA-N |
| SMILES | CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=C(C=C3)C(=O)O)Cl |
| Reference | </br>1:Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites. Bullard KM, Broccardo C, Keenan SM.Malar J. 2015 Apr 8;14:147. doi: 10.1186/s12936-015-0655-x. PMID: 25879664 Free PMC Article</br>2:VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. Ringer L, Sirajuddin P, Yenugonda VM, Ghosh A, Divito K, Trabosh V, Patel Y, Brophy A, Grindrod S, Lisanti MP, Rosenthal D, Brown ML, Avantaggiati ML, Rodriguez O, Albanese C.Cancer Biol Ther. 2010 Aug 15;10(4):320-5. Epub 2010 Aug 3. PMID: 20574155 Free PMC Article |
