For research use only. Not for therapeutic Use.
PVHD121 is a potent mitotic inhibitor, an antimitotic agent that selectively disturbs microtubule formation at centrosomes during mitosis. PVHD121 was shown to have strong antiproliferative activity against various tumor-derived cell lines, including A549 (lung), NCI-H460 (lung), HCT116 (colon), MCF7 (breast), PC3 (prostate), and HeLa (cervical) cells with IC50 values from 0.1 to 0.3 μM. Potential tool for studying the molecular biology of mitosis.
KEYWORDS: PVHD121 | supplier | Microtubule inhibitor | PVHD 121 | PVHD-121 | CAS [187336-16-9] | Cytoskeleton | Tubulin | Inhibitor | Proteins
| Catalog Number | I047644 |
| CAS Number | 187336-16-9 |
| Molecular Formula | C17H16N2O2 |
| Purity | ≥95% |
| IUPAC Name | 1-(4-methoxyphenyl)-1-quinazolin-4-ylethanol |
| InChI | InChI=1S/C17H16N2O2/c1-17(20,12-7-9-13(21-2)10-8-12)16-14-5-3-4-6-15(14)18-11-19-16/h3-11,20H,1-2H3 |
| SMILES | CC(C1=CC=C(C=C1)OC)(C2=NC=NC3=CC=CC=C32)O |
| Reference | K Kuroiwa et al. Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents. ACS Med Chem Lett. 2015 Jan 10;6(3):287-91. JI Sawada et al. Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative. Mol Pharmacol. 2019;96(5):609-618. |
