For research use only. Not for therapeutic Use.
Px-104（Cat No.:I008917）is a promising investigational compound recognized for its potential in neuroprotection, particularly in treating neurodegenerative conditions. It functions primarily as an antioxidant, targeting and neutralizing reactive oxygen species (ROS) to reduce oxidative stress, which is a key factor in cellular aging and neurodegeneration. Px-104 is of particular interest for its effectiveness in crossing the blood-brain barrier, making it valuable for central nervous system (CNS) applications. Its targeted action supports ongoing research in Alzheimer’s, Parkinson’s, and other disorders, aiming to prevent or slow neurodegenerative progression.
| Catalog Number | I008917 |
| CAS Number | 1268244-88-7 |
| Synonyms | Px-104; Px104; Px 104; Px-102; Px102; Px 102;4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid |
| Molecular Formula | C29H22Cl3NO4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 4-[2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]cyclopropyl]benzoic acid |
| InChI | InChI=1S/C29H22Cl3NO4/c30-23-2-1-3-24(31)26(23)27-22(28(37-33-27)16-6-7-16)14-36-18-10-11-19(25(32)12-18)21-13-20(21)15-4-8-17(9-5-15)29(34)35/h1-5,8-12,16,20-21H,6-7,13-14H2,(H,34,35) |
| InChIKey | XBUXXJUEBFDQHD-UHFFFAOYSA-N |
| SMILES | C1CC1C2=C(C(=NO2)C3=C(C=CC=C3Cl)Cl)COC4=CC(=C(C=C4)C5CC5C6=CC=C(C=C6)C(=O)O)Cl |
| Reference | </br>1:Gege C, Kinzel O, Steeneck C, Schulz A, Kremoser C. Knocking on FXR/’s door: the /hammerhead/-structure series of FXR agonists – amphiphilic isoxazoles with potent in vitro and in vivo activities. Curr Top Med Chem. 2014;14(19):2143-58. Review. PubMed PMID: 25388536. |
