PX-478 hydrochloride

• CAT Number: I004578
• CAS Number: 685898-44-6
• Molecular Formula: C₁₃H₂₀Cl₄N₂O
• Molecular Weight: 394.11
• Purity: ≥95%
• Synonyms: (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
• Target: HIF
• Solubility: H2O: ≥ 35 mg/mL
• Storage: Store at -20°C
• IC50: 20-30 μM
• IUPAC Name: 4-[(2S)-2-amino-2-carboxyethyl]-N,N-bis(2-chloroethyl)benzeneamine oxide;dihydrochloride
• InChI: InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1
• InChIKey: GIGCDIVNDFQKRA-LTCKWSDVSA-N
• SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

PX-478 hydrochloride（Cat No.:I004578）is a small-molecule inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), a transcription factor overexpressed in many cancers and linked to tumor growth, angiogenesis, and resistance to therapies. By inhibiting HIF-1α, PX-478 disrupts cellular adaptation to low oxygen, impairing cancer cell survival under hypoxic conditions. It has demonstrated anticancer activity across various solid tumors and hematologic malignancies, making it valuable in cancer research. PX-478’s role in targeting hypoxia-driven pathways positions it as a promising candidate in developing therapies that improve treatment outcomes in aggressive, hypoxic tumors.

Reference

[1]. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437.
[2]. Welsh S, et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther. 2004 Mar;3(3):233-244.