For research use only. Not for therapeutic Use.
PXYC1 is a ribosomal protein S1 (RpsA) antagonist with Kds of 0.81 and 0.31 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb)[1].
| Catalog Number | I043550 |
| CAS Number | 865098-81-3 |
| Synonyms | ethyl 2-[(6-oxo-1,7-dihydropurin-2-yl)sulfanyl]acetate |
| Molecular Formula | C9H10N4O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C9H10N4O3S/c1-2-16-5(14)3-17-9-12-7-6(8(15)13-9)10-4-11-7/h4H,2-3H2,1H3,(H2,10,11,12,13,15) |
| InChIKey | YUQGXHIIAOIQEZ-UHFFFAOYSA-N |
| SMILES | CCOC(=O)CSC1=NC2=C(C(=O)N1)NC=N2 |
| Reference | [1]. Yazhuang Dai, et al. Discovery and evaluation of new compounds targeting ribosomal protein S1 in antibiotic-resistant Mycobacterium Tuberculosis. Eur J Med Chem. 2020 Jun 15;196:112317. |
