PY108

• CAT Number: I047674
• CAS Number: 2378039-21-3
• Molecular Formula: C15H9N3O
• Molecular Weight: 247.25
• Purity: ≥95%
• IUPAC Name: 6-(1H-indole-3-carbonyl)pyridine-2-carbonitrile
• InChI: InChI=1S/C15H9N3O/c16-8-10-4-3-7-14(18-10)15(19)12-9-17-13-6-2-1-5-11(12)13/h1-7,9,17H
• SMILES: C1=CC=C2C(=C1)C(=CN2)C(=O)C3=CC=CC(=N3)C#N

PY108 is a potent, orally bioavailable aryl hydrocarbon receptor (AHR) agonist with an EC50 value of 2.5 nM.
KEYWORDS: PY108 | Supplier | AHR agonist | PY 108 | PY-108 | CAS [2378039-21-3] | AHR | Agonist | Transcription Factors | Gut immunity | Inflammatory bowel disease | IBD | Immune modulator

Reference

J Chen et al. Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists. Sci Adv. 2020 Jan 15;6(3):eaay8230.