PY109

• CAT Number: I047675
• CAS Number: 2378039-23-5
• Molecular Formula: C15H9F3N2O
• Molecular Weight: 290.24
• Purity: ≥95%
• IUPAC Name: 1H-indol-3-yl-[6-(trifluoromethyl)pyridin-2-yl]methanone
• InChI: InChI=1S/C15H9F3N2O/c16-15(17,18)13-7-3-6-12(20-13)14(21)10-8-19-11-5-2-1-4-9(10)11/h1-8,19H
• SMILES: C1=CC=C2C(=C1)C(=CN2)C(=O)C3=NC(=CC=C3)C(F)(F)F

PY109 is a potent, orally bioavailable aryl hydrocarbon receptor (AHR) agonist with an EC50 value of 1.2 nM.
KEYWORDS: PY109 | Supplier | AHR agonist | PY 109 | PY-109 | CAS [2378039-23-5] | AHR | Agonist | Transcription Factors | Gut immunity | Inflammatory bowel disease | IBD | Immune modulator

Reference

J Chen et al. Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists. Sci Adv. 2020 Jan 15;6(3):eaay8230.