Pyclen

• CAT Number: I012279
• CAS Number: 78668-34-5
• Molecular Formula: C11H18N4
• Molecular Weight: 206.29
• Purity: ≥95%
• Synonyms: 3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene; 1,4,7,10-Tetraaza-2,6-pyridinophane
• IUPAC Name: 3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene
• InChI: InChI=1S/C11H18N4/c1-2-10-8-13-6-4-12-5-7-14-9-11(3-1)15-10/h1-3,12-14H,4-9H2
• InChIKey: LNMUPMQUMCDOKO-UHFFFAOYSA-N
• SMILES: C1CNCC2=NC(=CC=C2)CNCCN1

Pyclen(CAT: I012279) is a potent inhibitor of cell death induced by oxidative stress and effectively prevents the aggregation of amyloid-beta (Aβ1-40) peptides triggered by Cu²⁺ ions. By chelating metal ions, Pyclen reduces metal-induced oxidative damage and disrupts the metal-mediated aggregation of amyloid-beta, a key pathological hallmark in Alzheimer’s disease. Its dual action in mitigating oxidative stress and inhibiting toxic protein aggregation highlights its therapeutic potential in neurodegenerative disease research. Pyclen offers promising applications in developing treatments aimed at slowing or preventing the progression of disorders like Alzheimer’s by targeting metal dysregulation and oxidative injury.