Pyflubumide

• CAT Number: I035237
• CAS Number: 926914-55-8
• Molecular Formula: C25H33F6N3O3
• Molecular Weight: 537.5474
• Purity: 98%
• Synonyms: Pyflubumide
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-Isobutyl-N-isobutyryl-1,3,5-trimethyl-4-(2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl)pyrazole-4-carboxanilide
• InChI: InChI=1S/C25H33F6N3O3/c1-15(2)14-21(6)22(17(5)33(7)32-21,23(37-8,24(26,27)28)25(29,30)31)20(36)34(19(35)16(3)4)18-12-10-9-11-13-18/h9-13,15-16H,14H2,1-8H3
• InChIKey: DSLUQJGWMNUQOY-UHFFFAOYSA-N
• SMILES: O=C(C1(C(C(F)(F)F)(OC)C(F)(F)F)=C(C)N(C)N=C1(CC(C)C)C)N(C(C(C)C)=O)C2=CC=CC=C2

Pyflubumide (Cat No.: I035237) is a novel acaricide developed for the control of mites in agricultural settings. It acts as a pro-acaricide, metabolized in target pests to its active form, which inhibits mitochondrial complex II (succinate dehydrogenase), disrupting energy production and leading to mite death. Pyflubumide is highly selective for mites, showing minimal toxicity to beneficial insects and pollinators. It is used on crops like fruits, vegetables, and ornamentals. Its unique mode of action makes it valuable for resistance management in integrated pest control programs.

Reference

1: Furuya T, Machiya K, Fujioka S, Nakano M, Inagaki K. Development of a novel acaricide, pyflubumide. J Pestic Sci. 2017 Aug 20;42(3):132-136. doi: 10.1584/jpestics.J17-02. PMID: 30363851; PMCID: PMC6183382.
2: Li QB, Liao M, Liu Q, Feng T, Xu ZY, Rui CH, Liu SZ. Design, Synthesis, and Biological Activities of Novel 1,3,5-Trimethylpyrazole-Containing Malonamide Derivatives. Molecules. 2019 Feb 3;24(3):562. doi: 10.3390/molecules24030562. PMID: 30717498; PMCID: PMC6385117.
3: Sugimoto N, Takahashi A, Ihara R, Itoh Y, Jouraku A, Van Leeuwen T, Osakabe M. QTL mapping using microsatellite linkage reveals target-site mutations associated with high levels of resistance against three mitochondrial complex II inhibitors in Tetranychus urticae. Insect Biochem Mol Biol. 2020 May 19;123:103410. doi: 10.1016/j.ibmb.2020.103410. Epub ahead of print. PMID: 32442626.
4: Van Leeuwen T, Tirry L, Yamamoto A, Nauen R, Dermauw W. The economic importance of acaricides in the control of phytophagous mites and an update on recent acaricide mode of action research. Pestic Biochem Physiol. 2015 Jun;121:12-21. doi: 10.1016/j.pestbp.2014.12.009. Epub 2014 Dec 12. PMID: 26047107.