For research use only. Not for therapeutic Use.
PYR01 is a potent HIV-1 nonnucleoside reverse transcriptase inhibitor. PYR01 is an also targeted activator of cell kill molecules eliminate cells expressing HIV-1[1].
| Catalog Number | I041172 |
| CAS Number | 2560576-15-8 |
| Synonyms | 5-(difluoromethyl)-3-[1-[(5-fluoro-2-oxo-1H-pyridin-3-yl)methyl]-6-oxo-4-(1,1,2,2-tetrafluoroethyl)pyrimidin-5-yl]oxy-2-methylbenzonitrile |
| Molecular Formula | C21H13F7N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H13F7N4O3/c1-9-11(5-29)2-10(17(23)24)4-14(9)35-15-16(21(27,28)20(25)26)31-8-32(19(15)34)7-12-3-13(22)6-30-18(12)33/h2-4,6,8,17,20H,7H2,1H3,(H,30,33) |
| InChIKey | VZPBEVWOYXRBLB-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1OC2=C(N=CN(C2=O)CC3=CC(=CNC3=O)F)C(C(F)F)(F)F)C(F)F)C#N |
| Reference | [1]. Carl J Balibar, et al. Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1. Sci Transl Med. 2023 Feb 22;15(684):eabn2038. |
