Pyr6

• CAT Number: I002830
• CAS Number: 245747-08-4
• Molecular Formula: C17H9F7N4O
• Molecular Weight: 418.27
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.49 uM
• IUPAC Name: N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-3-fluoropyridine-4-carboxamide
• InChI: InChI=1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)
• InChIKey: XZIQSOZOLJJMFN-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1NC(=O)C2=C(C=NC=C2)F)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F

Pyr6（Cat No.:I002830）is a small molecule that functions as a selective inhibitor of the protein kinase PYK2 (also known as PTK2B), which is involved in various cellular processes, including cell adhesion, migration, and signal transduction. PYK2 plays a role in tumor progression, inflammation, and neurological functions, making Pyr6 a compound of interest in cancer and neurodegenerative disease research. By inhibiting PYK2, Pyr6 may help modulate these processes, offering potential therapeutic applications for conditions such as cancer metastasis, Alzheimer’s disease, and other diseases related to abnormal cell signaling. Further clinical studies are ongoing.

Reference

[1]. Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-22.