For research use only. Not for therapeutic Use.
Pyridinium bisretinoid A2E-d4 TFA, a premium pharmaceutical research compound designed for advanced ophthalmic and age-related macular degeneration (AMD) studies. As a deuterated analog of Pyridinium bisretinoid A2E, it offers enhanced stability and improved isotopic tracking. Pyridinium bisretinoid A2E-d4 TFA is ideal for use in pharmacological and biochemical research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel therapies for retinal diseases and AMD. Trusted by leading laboratories, Pyridinium bisretinoid A2E-d4 TFA is your go-to solution for cutting-edge ophthalmic research. Unlock new possibilities in retinal health with Pyridinium bisretinoid A2E-d4 TFA, where innovation meets reliability.
| Catalog Number | S000201 |
| Molecular Formula | C44H54D4F3NO3 |
| Purity | ≥95% |
| IUPAC Name | 1,1,2,2-tetradeuterio-2-[2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohexen-1-yl)octa-1,3,5,7-tetraenyl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohexen-1-yl)hexa-1,3,5-trienyl]pyridin-1-ium-1-yl]ethanol;2,2,2-trifluoroacetate |
| InChI | InChI=1S/C42H58NO.C2HF3O2/c1-32(20-22-39-35(4)17-12-25-41(39,6)7)14-10-16-34(3)30-38-31-37(24-27-43(38)28-29-44)19-11-15-33(2)21-23-40-36(5)18-13-26-42(40,8)9;3-2(4,5)1(6)7/h10-11,14-16,19-24,27,30-31,44H,12-13,17-18,25-26,28-29H2,1-9H3;(H,6,7)/q+1;/p-1/b16-10+,19-11+,22-20+,23-21+,32-14+,33-15+,34-30+;/i28D2,29D2; |
| InChIKey | ZFPRGIJSRMWZMS-CFOVJWFZSA-M |
| SMILES | [2H]C([2H])(C([2H])([2H])O)[N+]1=C(C=C(C=C1)/C=C/C=C(\C)/C=C/C2=C(CCCC2(C)C)C)/C=C(\C)/C=C/C=C(\C)/C=C/C3=C(CCCC3(C)C)C.C(=O)(C(F)(F)F)[O-] |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-218. [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [3]. Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555. [4]. S. Ben-Shabat, et al; Elucidating the Role of Pyridinium bis-Retinoid(A2E) in Retinal Pigment Epithelium (RPE) Cell Damages. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2201. |
