Pyridinium bisretinoid A2E TFA

• CAT Number: I041236
• CAS Number: 1821308-73-9
• Molecular Formula: C44H58F3NO3
• Molecular Weight: 705.93
• Purity: ≥95%
• Synonyms: 2-[2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohexen-1-yl)octa-1,3,5,7-tetraenyl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohexen-1-yl)hexa-1,3,5-trienyl]pyridin-1-ium-1-yl]ethanol;2,2,2-trifluoroacetate
• InChI: InChI=1S/C42H58NO.C2HF3O2/c1-32(20-22-39-35(4)17-12-25-41(39,6)7)14-10-16-34(3)30-38-31-37(24-27-43(38)28-29-44)19-11-15-33(2)21-23-40-36(5)18-13-26-42(40,8)9;3-2(4,5)1(6)7/h10-11,14-16,19-24,27,30-31,44H,12-13,17-18,25-26,28-29H2,1-9H3;(H,6,7)/q+1;/p-1/b16-10+,19-11+,22-20+,23-21+,32-14+,33-15+,34-30+
• InChIKey: ZFPRGIJSRMWZMS-KFKWWMHDSA-M
• SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C2=CC(=[N+](C=C2)CCO)/C=C(\C)/C=C/C=C(\C)/C=C/C3=C(CCCC3(C)C)C)/C.C(=O)(C(F)(F)F)[O-]

Pyridinium bisretinoid A2E TFA（Cat No.:I041236）is a chemically modified form of A2E, a toxic byproduct of the visual cycle that accumulates in retinal cells and is associated with age-related macular degeneration (AMD). A2E forms when retinol and retinal molecules react with proteins in the retina, contributing to oxidative damage and retinal degeneration. The trifluoroacetate (TFA) salt form of A2E enhances its stability and solubility for research purposes. Researchers use Pyridinium bisretinoid A2E TFA to study the molecular mechanisms underlying retinal diseases and to explore potential therapeutic interventions targeting A2E accumulation and toxicity.