Pyridostatin TFA salt

• CAT Number: I008846
• CAS Number: 1472611-44-1 (TFA salt); 1085412-37-8 (free base); 1629261-49-9 (HCl salt).
• Molecular Formula: C37H35F9N8O11
• Molecular Weight: 938.72
• Purity: ≥95%
• Target: G-quadruplex
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• SMILES: O=C(C1=NC(C(NC2=NC3=CC=CC=C3C(OCCN)=C2)=O)=CC(OCCN)=C1)NC4=NC5=CC=CC=C5C(OCCN)=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Pyridostatin TFA salt (Cat No.: I008846) is a small molecule G-quadruplex stabilizer that selectively binds to G-rich DNA sequences, promoting the formation and stabilization of G-quadruplex structures. These structures can regulate gene expression and are often found in oncogene promoters and telomeres. Pyridostatin is widely used in cancer research to investigate genomic instability and telomere maintenance. The TFA salt form enhances its solubility and handling. Pyridostatin serves as a valuable tool in exploring G-quadruplex-targeted therapies and understanding DNA secondary structure dynamics.

Reference

1: Marchand A, Granzhan A, Iida K, Tsushima Y, Ma Y, Nagasawa K, Teulade-Fichou M, Gabelica V. Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes. J Am Chem Soc. 2015 Jan 6. [Epub ahead of print] PubMed PMID: 25525863.2:Murat P, Zhong J, Lekieffre L, Cowieson NP, Clancy JL, Preiss T, Balasubramanian S, Khanna R, Tellam J. G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation. Nat Chem Biol. 2014 May;10(5):358-64. doi: 10.1038/nchembio.1479. Epub 2014 Mar 16. PubMed PMID: 24633353; PubMed Central PMCID: PMC4188979.