For research use only. Not for therapeutic Use.
Pyridoxal 5’-Phosphate (Cat No.:R047923) is the active coenzyme form of vitamin B6, essential in numerous enzymatic reactions in amino acid metabolism, including transamination, decarboxylation, and deamination. It plays a pivotal role in neurotransmitter synthesis, heme production, and gluconeogenesis. PLP serves as a cofactor for over 140 enzymes, making it vital for cellular function and metabolic regulation. Widely used in biochemical and pharmaceutical research, Pyridoxal 5’-Phosphate is crucial for studying enzyme mechanisms, metabolic pathways, and the role of vitamin B6 deficiencies in neurological and metabolic disorders.
| Catalog Number | R047923 |
| CAS Number | 54-47-7 |
| Synonyms | 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde; Pyridoxal Phosphate; Pyridoxal 5-(Dihydrogen Phosphate); 2-Methyl-3-hydroxy-4-formyl-5-?pyridyl-methylphosphoric Acid; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-?isonicotinaldehyde 5-Ph |
| Molecular Formula | C₈H₁₀NO₆P |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | -20°C |
| IUPAC Name | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate |
| InChI | InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
| InChIKey | NGVDGCNFYWLIFO-UHFFFAOYSA-N |
| SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O |
| Reference | </br>1:Pyridoxal 5/’-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides. Wang Q, He XM, Chen X, Zhu GT, Wang RQ, Feng YQ.J Chromatogr A. 2017 May 26;1499:30-37. doi: 10.1016/j.chroma.2017.03.085. Epub 2017 Apr 1. PMID: 28390667 </br>2:Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5/’-phosphate in aspartate aminotransferase. Dajnowicz S, Parks JM, Hu X, Gesler K, Kovalevsky AY, Mueser TC.J Biol Chem. 2017 Apr 7;292(14):5970-5980. doi: 10.1074/jbc.M116.774588. Epub 2017 Feb 23. PMID: 28232482 </br>3:The dietary protein paradox and threonine <sup>15</sup> N-depletion: Pyridoxal-5/’-phosphate enzyme activity as a mechanism for the δ<sup>15</sup> N trophic level effect. Fuller BT, Petzke KJ.Rapid Commun Mass Spectrom. 2017 Apr 30;31(8):705-718. doi: 10.1002/rcm.7835. PMID: 28181729 </br>4:Biomimetic Chirality Sensing with Pyridoxal-5/’-phosphate. Pilicer SL, Bakhshi PR, Bentley KW, Wolf C.J Am Chem Soc. 2017 Feb 8;139(5):1758-1761. doi: 10.1021/jacs.6b12056. Epub 2017 Jan 30. PMID: 28128945 </br>5:Identification and characterization of a pyridoxal 5/’-phosphate phosphatase in the silkworm (Bombyx mori). Huang S, Han C, Ma Z, Zhou J, Zhang J, Huang L.Comp Biochem Physiol B Biochem Mol Biol. 2017 Mar;205:39-45. doi: 10.1016/j.cbpb.2017.01.003. Epub 2017 Jan 10. PMID: 28089883 </br>6:Role of Pyridoxal 5/’-Phosphate at the Titanium Implant Interface In Vivo: Increased Hemophilicity, Inactive Platelet Adhesion, and Osteointegration. Lee JS, Kim K, Park JP, Cho SW, Lee H.Adv Healthc Mater. 2017 Mar;6(5). doi: 10.1002/adhm.201600962. Epub 2017 Jan 12. PMID: 28081293 </br>7:Measurement of pyridoxal 5/’-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children. Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Toda S, Imai K, Hamano SI, Okanishi T, Yoshinaga H, Kobayashi K.Clin Chim Acta. 2017 Mar;466:1-5. doi: 10.1016/j.cca.2016.12.027. Epub 2016 Dec 28. PMID: 28040557 </br>8:New Insights Emerging from Recent Investigations on Human Group II Pyridoxal 5/’-Phosphate Decarboxylases. Paiardini A, Giardina G, Rossignoli G, Voltattorni CB, Bertoldi M.Curr Med Chem. 2017;24(3):226-244. doi: 10.2174/0929867324666161123093339. Review. PMID: 27881066 </br>9:Applications of vitamin B6 cofactor pyridoxal 5/’-phosphate and pyridoxal 5/’-phosphate crowned gold nanoparticles for optical sensing of metal ions. Bothra S, Upadhyay Y, Kumar R, Sahoo SK.Spectrochim Acta A Mol Biomol Spectrosc. 2017 Mar 5;174:1-6. doi: 10.1016/j.saa.2016.11.014. Epub 2016 Nov 13. PMID: 27865135 </br>10:Serum B<sub>6</sub> vitamers (pyridoxal 5/’-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations. Huang JY, Butler LM, Midttun Ø, Koh WP, Ueland PM, Wang R, Jin A, Gao YT, Yuan JM.Cancer Causes Control. 2016 Dec;27(12):1447-1456. Epub 2016 Nov 9. PMID: 27830400 |
