Pyridoxine 5'-phosphate

For research use only. Not for therapeutic Use.

  • CAT Number: I035262
  • CAS Number: 8059-24-3
  • Molecular Formula: C8H12NO5P
  • Molecular Weight: 233.15
  • Purity: 98%
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Pyridoxine 5′-phosphate(Cat No.:I035262), also known as Vitamin B6, serves as a vital enzyme cofactor in the biosynthesis of several crucial neurotransmitters, including serotonin, dopamine, epinephrine, norepinephrine, and gamma-aminobutyric acid (GABA). PLP plays a fundamental role in the conversion of precursor molecules into these neurotransmitters, facilitating their synthesis and regulation within the central nervous system. By supporting the production of these neurotransmitters, pyridoxine 5′-phosphate is involved in various physiological processes, including mood regulation, cognition, stress response, and overall neurotransmitter balance.


Catalog Number I035262
CAS Number 8059-24-3
Synonyms

Pyridoxine 5'-phosphate; PLP; Vitamin B6;

Molecular Formula C8H12NO5P
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage 2-8°C
IUPAC Name (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate
InChI InChI=1S/C8H12NO5P/c1-5-7(4-14-15(11,12)13)3-9-6(2)8(5)10/h3,10H,4H2,1-2H3,(H2,11,12,13)
InChIKey RBCOYOYDYNXAFA-UHFFFAOYSA-N
SMILES O=P(O)(O)OCC1=C(C)C(O)=C(C)N=C1
Reference

1: Rosenberg J, Ischebeck T, Commichau FM. Vitamin B6 metabolism in microbes and approaches for fermentative production. Biotechnol Adv. 2017 Jan – Feb;35(1):31-40. doi: 10.1016/j.biotechadv.2016.11.004. Epub 2016 Nov 24. Review. PubMed PMID: 27890703.
2: di Salvo ML, Safo MK, Contestabile R. Biomedical aspects of pyridoxal 5′-phosphate availability. Front Biosci (Elite Ed). 2012 Jan 1;4:897-913. Review. PubMed PMID: 22201923.
3: di Salvo ML, Contestabile R, Safo MK. Vitamin B(6) salvage enzymes: mechanism, structure and regulation. Biochim Biophys Acta. 2011 Nov;1814(11):1597-608. doi: 10.1016/j.bbapap.2010.12.006. Epub 2010 Dec 20. Review. PubMed PMID: 21182989.
4: Garrido-Franco M. Pyridoxine 5′-phosphate synthase: de novo synthesis of vitamin B6 and beyond. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):92-7. Review. PubMed PMID: 12686115.
5: di Salvo ML, Safo MK, Musayev FN, Bossa F, Schirch V. Structure and mechanism of Escherichia coli pyridoxine 5′-phosphate oxidase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):76-82. Review. PubMed PMID: 12686112.

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