For research use only. Not for therapeutic Use.
Pyrimethamine（Cat No.:A000474）is an antiparasitic drug primarily used to treat malaria and toxoplasmosis. It works by inhibiting dihydrofolate reductase, an enzyme essential for the synthesis of folic acid in parasites, thereby disrupting DNA synthesis and cell division. Pyrimethamine is often used in combination with sulfonamides to enhance its effectiveness against Plasmodium species, the causative agents of malaria, and Toxoplasma gondii, responsible for toxoplasmosis. Its ability to selectively target parasitic enzymes makes it a valuable tool in parasitology and a critical drug in treating parasitic infections.
| Catalog Number | A000474 |
| CAS Number | 58-14-0 |
| Synonyms | 58-14-0; Daraprim; Chloridine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; Chloridin |
| Molecular Formula | C12H13ClN4 |
| Purity | ≥95% |
| Target | Anti-infection |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | -20°C |
| IUPAC Name | 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |
| InChI | InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17) |
| InChIKey | WKSAUQYGYAYLPV-UHFFFAOYSA-N |
| SMILES | CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl |
| Reference | 1: Salman S, Davis TME. Regarding /Lactation Status and Studies of Pyrimethamine 2: de Kock M, Tarning J, Barnes KI, Denti P. Response to /Lactation Status and 3: Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, Jones 4: Ben-Harari RR, Goodwin E, Casoy J. Adverse Event Profile of 5: Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, 6: Owusu-Boateng I, Anto F. Intermittent preventive treatment of malaria in 7: Okell LC, Griffin JT, Roper C. Mapping sulphadoxine-pyrimethamine-resistant 8: Abugri DA, Witola WH, Russell AE, Troy RM. In vitro activity of the <br> <br> |
