Pyrithioxin

For research use only. Not for therapeutic Use.

  • CAT Number: I000411
  • CAS Number: 1098-97-1
  • Molecular Formula: C16H20N2O4S2
  • Molecular Weight: 368.47
  • Purity: ≥95%
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Pyrithioxin (CAT: I000411) is a neurodynamic compound that has been studied for its potential therapeutic applications in cerebral infarction patients with hemiplegia. It has been used in combination with a short period of hyperventilation (HV) as a treatment approach. The rationale behind this treatment strategy is to enhance oxygen supply to the ischemic brain region by inducing temporary hyperventilation and simultaneously administering pyrithioxin to support neurodynamic processes. By combining these approaches, it is believed that the recovery and functional outcomes in hemiplegic patients with cerebral infarction may be improved.


Catalog Number I000411
CAS Number 1098-97-1
Molecular Formula C16H20N2O4S2
Purity ≥95%
Target Endogenous Metabolite
Solubility 10mM in DMSO
Storage Store at -20°C
Overview of Clinical Research

<span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Pyritinol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders.</span></span></span></span>

IUPAC Name 5-[[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyldisulfanyl]methyl]-4-(hydroxymethyl)-2-methylpyridin-3-ol
InChI InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3
InChIKey SIXLXDIJGIWWFU-UHFFFAOYSA-N
SMILES CC1=NC=C(C(=C1O)CO)CSSCC2=CN=C(C(=C2CO)O)C
Reference

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1:[Disappearance of immunologic abnormalities in rheumatoid nodulosis. Role of pyrithioxin]. Carli P, de Jaureguiberry JP, Paris JF, Chagnon A.Presse Med. 1990 Jun 16;19(24):1152. French. No abstract available. PMID: 2141935<br />
2:Increase in acetylcholine concentrations in the brain of /&#39;old/&#39; rats following treatment with pyrithioxin (Encephabol). Martin KJ, Vyas S.Br J Pharmacol. 1987 Mar;90(3):561-5. PMID: 3567461 Free PMC Article<br />
3:Effects of the chronic administration of pyrithioxin on behaviour and cholinergic function in young and aged rats. Marston HM, Martin KJ, Robbins TW.J Psychopharmacol. 1987 Jan;1(4):237-43. doi: 10.1177/026988118700100404. PMID: 22159136<br />
4:[Pyrithioxin and rheumatoid polyarthritis]. Crouzet J, Beraneck L.Rev Rhum Mal Osteoartic. 1986 Jan;53(1):45-8. French. PMID: 3704512<br />
5:[Acute polymyositis complicating rheumatoid arthritis treated with pyrithioxin]. Tr&egrave;ves R, Tabaraud F, Arnaud M, Jacob P, Hugon J, Lubeau M, Burki F, Desproges-Gotteron R.Rev Rhum Mal Osteoartic. 1984 May;51(5):283-5. French. No abstract available. PMID: 6740192<br />
6:[Lichenoid eruption during the treatment of rheumatoid arthritis with pyrithioxin]. Crouzet J, Fourot J, Julie JH, Duterque M.Rev Rhum Mal Osteoartic. 1983 Dec;50(12):827-8. French. No abstract available. PMID: 6229868<br />
7:[Extramembranous glomerulonephritis in rheumatoid polyarthritis. Possible role of pyrithioxin]. Tr&egrave;ves R, Desproges-Gotteron R, Benevent D, Benevent J, Leroux-Robert C.Rev Rhum Mal Osteoartic. 1983 Apr;50(4):309-10. French. No abstract available. PMID: 6879101<br />
8:[Retrospective study of the effects of D-penicillamine and pyrithioxin in the treatment of rheumatoid arthritis]. Clerc D, Salli&egrave;re D, Segond P, Bisson M, Massias P.Rev Rhum Mal Osteoartic. 1983 Apr;50(4):281-7. French. PMID: 6879095<br />
9:[Pyrithioxin in the treatment of patients with rheumatoid arthritis (comparative study with D-penicillamine)]. Tosković B.Reumatizam. 1983;30(3):60-8. Croatian. No abstract available. PMID: 6351211<br />
10:[Toxic hepatitis induced by pyrithioxin during rheumatoid polyarthritis]. Valat J, Gatti P, Sichere P, Metman E, Dorval ED.Nouv Presse Med. 1982 May 22;11(24):1875. French. No abstract available. PMID: 7110937

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