Pyronaridine Tetraphosphate

• CAT Number: R063474
• CAS Number: 76748-86-2
• Molecular Formula: C29H44ClN5O18P4
• Molecular Weight: 910.03
• Purity: ≥95%
• Synonyms: Benzo[b]-1,5-naphthyridine Phenol Derivative Phosphate; Malaridine Phosphate (1:4); 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol Phosphate(1:4); 4-((7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl
• Target: MDR multidrug resistance
• Solubility: >12.25mg/mL in DMSO
• Storage: Store at RT
• IUPAC Name: 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol;phosphoric acid
• InChI: InChI=1S/C29H32ClN5O2.4H3O4P/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35;4*1-5(2,3)4/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32);4*(H3,1,2,3,4)
• InChIKey: YKUQEKXHQFYULM-UHFFFAOYSA-N
• SMILES: COC1=NC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)NC4=CC(=C(C(=C4)CN5CCCC5)O)CN6CCCC6.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O

Pyronaridine Tetraphosphate（Cat No.:R063474）is an antimalarial drug widely used in combination therapies to treat Plasmodium falciparum and Plasmodium vivax infections. It disrupts hemozoin formation, causing toxic heme accumulation and parasite death. Often paired with artesunate, it enhances efficacy and combats drug resistance, making it a cornerstone in artemisinin-based combination therapies (ACTs). Pyronaridine Tetraphosphate is well-tolerated and effective against multidrug-resistant malaria strains, offering a long half-life and robust parasite clearance. Its role in malaria control programs highlights its importance in global efforts to eradicate this life-threatening disease.