For research use only. Not for therapeutic Use.
Pyropheophorbide-a methyl ester (MPPa) is a PDT photosensitizer, and is also a semisynthetic natural product derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay showed that MPPa had no dark cytotoxicity.
| Catalog Number | R063710 |
| CAS Number | 6453-67-4 |
| Synonyms | (3S,4S)-9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic Acid Methyl Ester;?(3S-trans)-9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic Acid Methyl Ester; 14-Ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-3-phorbinep |
| Molecular Formula | C₃₄H₃₆N₄O₃ |
| Purity | ≥95% |
| Target | Apoptosis |
| Storage | 3 years -20C powder |
| Reference | </br>1:Evaluation of one- and two-photon activated photodynamic therapy with pyropheophorbide-a methyl ester in human cervical, lung and ovarian cancer cells. Luo T, Wilson BC, Lu QB.J Photochem Photobiol B. 2014 Mar 5;132:102-10. doi: 10.1016/j.jphotobiol.2014.02.002. Epub 2014 Feb 15. PMID: 24607610 </br>2:Sonodynamic action of pyropheophorbide-a methyl ester induces mitochondrial damage in liver cancer cells. Xu J, Xia X, Leung AW, Xiang J, Jiang Y, Yu H, Bai D, Li X, Xu C.Ultrasonics. 2011 May;51(4):480-4. doi: 10.1016/j.ultras.2010.11.014. Epub 2010 Dec 3. PMID: 21183195 </br>3:Optimizing photodynamic therapy by liposomal formulation of the photosensitizer pyropheophorbide-a methyl ester: in vitro and ex vivo comparative biophysical investigations in a colon carcinoma cell line. Guelluy PH, Fontaine-Aupart MP, Grammenos A, Lécart S, Piette J, Hoebeke M.Photochem Photobiol Sci. 2010 Sep 24;9(9):1252-60. doi: 10.1039/c0pp00100g. Epub 2010 Aug 12. PMID: 20714673 </br>4:Sonodynamic action of pyropheophorbide-a methyl ester in liver cancer cells. Xu J, Xia X, Wang X, Xu C, Wang P, Xiang J, Jiang Y, Leung AW.J Ultrasound Med. 2010 Jul;29(7):1031-7. PMID: 20587426 </br>5:Selective time-resolved binding of copper(II) by pyropheophorbide-a methyl ester. Ghosh I, Saleh N, Nau WM.Photochem Photobiol Sci. 2010 May;9(5):649-54. doi: 10.1039/c0pp00002g. Epub 2010 Feb 22. PMID: 20442923 </br>6:Apoptosis and expression of cytokines triggered by pyropheophorbide-a methyl ester-mediated photodynamic therapy in nasopharyngeal carcinoma cells. Li KM, Sun X, Koon HK, Leung WN, Fung MC, Wong RN, Lung ML, Chang CK, Mak NK.Photodiagnosis Photodyn Ther. 2006 Dec;3(4):247-58. doi: 10.1016/j.pdpdt.2006.09.001. Epub 2006 Oct 17. PMID: 25046989 </br>7:Photodynamic effects of pyropheophorbide-a methyl ester in nasopharyngeal carcinoma cells. Xu CS, Leung AW.Med Sci Monit. 2006 Aug;12(8):BR257-62. Epub 2006 Jul 12. PMID: 16865057 </br>8:Physical and chemical properties of pyropheophorbide-a methyl ester in ethanol, phosphate buffer and aqueous dispersion of small unilamellar dimyristoyl-L-alpha-phosphatidylcholine vesicles. Delanaye L, Bahri MA, Tfibel F, Fontaine-Aupart MP, Mouithys-Mickalad A, Heine B, Piette J, Hoebeke M.Photochem Photobiol Sci. 2006 Mar;5(3):317-25. Epub 2006 Jan 12. PMID: 16520867 </br>9:Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Sun X, Leung WN.Photochem Photobiol. 2002 Jun;75(6):644-51. PMID: 12081327 </br>10:Pyropheophorbide-a methyl ester-mediated photosensitization activates transcription factor NF-kappaB through the interleukin-1 receptor-dependent signaling pathway. Matroule JY, Bonizzi G, Morlière P, Paillous N, Santus R, Bours V, Piette J.J Biol Chem. 1999 Jan 29;274(5):2988-3000. PMID: 9915837 Free Article |
