Pyrrocaine

• CAT Number: I035280
• CAS Number: 2210-77-7
• Molecular Formula: C14H20N2O
• Molecular Weight: 232.33
• Purity: 98%
• Synonyms: Pyrrocaine; EN-1010; EN1010; EN 1010; NSC52644; NSC-52644; NSC 52644
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-(2,6-dimethylphenyl)-2-pyrrolidin-1-ylacetamide
• InChI: InChI=1S/C14H20N2O/c1-11-6-5-7-12(2)14(11)15-13(17)10-16-8-3-4-9-16/h5-7H,3-4,8-10H2,1-2H3,(H,15,17)
• InChIKey: OYCGKECKIVYHTN-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2

Pyrrocaine（Cat No.:I035280）is a local anesthetic agent that functions by inhibiting nerve signal transmission, providing temporary numbness and pain relief in medical procedures. It is chemically related to procaine but has a more stable molecular structure, which may offer enhanced duration of action. Pyrrocaine is used in various clinical settings, including dental procedures, minor surgeries, and diagnostic tests, to reduce discomfort. It works by blocking sodium channels in nerve fibers, preventing the propagation of pain signals to the brain. Its safety profile and efficacy make it a useful option for localized anesthesia.

Reference

1: Olech E. Pyrrocaine HCl – A Preliminary Clinical Study of Its Uses in Oral Surgery. J Am Dent Soc Anesthesiol. 1963 Oct;10(8):224-9. PMID: 19598995; PMCID: PMC2067883.
2: Zsigmond EK, Patterson RL. Double-blind evaluation of a new local anesthetic agents, pyrrocaine hydrochloride, for nerve block anesthesia. Anesth Analg. 1969 Jan-Feb;48(1):66-74. PMID: 4883831.
3: de Verneuil H, Deybach JC, Phung N, Da Silva V, Nordmann Y. Study of anaesthetic agents for their ability to elicit porphyrin biosynthesis in chick embryo liver. Biochem Pharmacol. 1983 Mar 15;32(6):1011-8. doi: 10.1016/0006-2952(83)90619-6. PMID: 6838647.
4: de Freitas JF. A rapid spectrophotometric assay of amide type dental anaesthetic agents. Aust Dent J. 1977 Jun;22(3):182-9. doi: 10.1111/j.1834-7819.1977.tb04486.x. PMID: 270977.