PZM21

• CAT Number: I008934
• CAS Number: 1997387-43-5
• Molecular Formula: C19H27N3O2S
• Molecular Weight: 361.50
• Purity: ≥95%
• Synonyms: PZM21; PZM-21; PZM 21.;1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 1-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-thiophen-3-ylpropan-2-yl]urea
• InChI: InChI=1S/C19H27N3O2S/c1-14(10-16-8-9-25-13-16)21-19(24)20-12-17(22(2)3)11-15-4-6-18(23)7-5-15/h4-9,13-14,17,23H,10-12H2,1-3H3,(H2,20,21,24)/t14-,17-/m0/s1
• InChIKey: MEDBIJOVZJEMBI-YOEHRIQHSA-N
• SMILES: O=C(N[C@@H](C)CC1=CSC=C1)NC[C@@H](N(C)C)CC2=CC=C(O)C=C2

PZM21(CAT: I008934) is a novel, functionally selective μ-opioid receptor (μOR) agonist and potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. It mediates G protein signaling with potency and efficacy comparable to morphine but exhibits significantly fewer adverse effects. In preclinical studies on mice, PZM21 demonstrated strong analgesic effects, albeit slightly less potent than morphine or TRV130, but with markedly reduced side effects, including minimal respiratory depression and less constipation, even at high doses. PZM21 is a valuable experimental compound in pain research, offering insights into developing safer opioid analgesics with reduced risks of addiction and side effects.