For research use only. Not for therapeutic Use.
PAR1/Gαq-specific allosteric inhibitor or negative allosteric modulator (NAM); Q94 selectively blocks PAR1/Gαq interaction and signalling
| Catalog Number | I011019 |
| CAS Number | 1052076-77-3 |
| Molecular Formula | C21H17ClN2.HCl |
| Purity | ≥95% |
| IUPAC Name | 2-benzyl-1-[(4-chlorophenyl)methyl]benzimidazole;hydrochloride |
| InChI | InChI=1S/C21H17ClN2.ClH/c22-18-12-10-17(11-13-18)15-24-20-9-5-4-8-19(20)23-21(24)14-16-6-2-1-3-7-16;/h1-13H,14-15H2;1H |
| SMILES | C1=CC=C(C=C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl.Cl |
| Reference | X Ding et al. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Gαq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol. Biol. Cell, 2008, 19(6), 2520-2533.
S Asteriti et al. Modulation of PAR1 signalling by benzimidazole compounds. Br. J. Pharmacol. 2012, 167, 80–94.
PF Mercer et al. Pulmonary Epithelium Is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. Am. J. Resp. Critical Care Med. 2009, 179(5), 414-425. |
