For research use only. Not for therapeutic Use.
QC6352 (Cat.No:I013177) is a potent inhibitor of the histone lysine demethylase KDM4C, with an IC50 of 35 nM. KDM4C, also known as JMJD2C, is an enzyme involved in the removal of methyl groups from specific histone lysine residues, thus regulating gene expression. QC6352’s ability to inhibit KDM4C makes it a valuable tool in epigenetic research and may have implications in the development of new therapeutic strategies for certain diseases.
| Catalog Number | I013177 |
| CAS Number | 1851373-36-8 |
| Molecular Formula | C₂₄H₂₅N₃O₂ |
| Purity | ≥95% |
| Target | Histone Demethylase |
| Solubility | DMSO |
| IUPAC Name | 3-[[(1R)-6-(N-methylanilino)-1,2,3,4-tetrahydronaphthalen-1-yl]methylamino]pyridine-4-carboxylic acid |
| InChI | InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1 |
| InChIKey | XSMABFRQESMONQ-SFHVURJKSA-N |
| SMILES | CN(C1=CC=CC=C1)C2=CC3=C(C=C2)C(CCC3)CNC4=C(C=CN=C4)C(=O)O |
| Reference | [1]. Chen YK, et al. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874.<br>[2]. Metzger E, et al. KDM4 inhibition targets breast cancer stem-like cells. Cancer Res. 2017 Sep 7. pii: canres.1754. |
