QCC-374

• CAT Number: I008936
• CAS Number: 1356331-63-9
• Molecular Formula: C28H33N3O2
• Molecular Weight: 443.59
• Purity: ≥95%
• Synonyms: QCC-374; QCC 374; QCC374;7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid
• Target: Prostaglandin Receptor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 7-[2,3-bis(4-methylphenyl)-7,8-dihydro-6H-pyrido[2,3-b]pyrazin-5-yl]heptanoic acid
• InChI: InChI=1S/C28H33N3O2/c1-20-10-14-22(15-11-20)26-27(23-16-12-21(2)13-17-23)30-28-24(29-26)8-7-19-31(28)18-6-4-3-5-9-25(32)33/h10-17H,3-9,18-19H2,1-2H3,(H,32,33)
• InChIKey: AYBWWXMNUCPFMW-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C2=NC3=C(N=C2C4=CC=C(C=C4)C)N(CCC3)CCCCCCC(=O)O

QCC-374（Cat No.:I008936）is a selective inhibitor of the enzyme quorum-sensing regulator (LuxR), which plays a crucial role in bacterial communication, or quorum sensing, involved in biofilm formation, virulence, and antibiotic resistance. By disrupting this process, QCC-374 aims to reduce bacterial pathogenicity without directly killing bacteria, offering a novel approach to antimicrobial therapy. It is particularly promising in the treatment of chronic bacterial infections, where biofilms and resistance mechanisms complicate traditional antibiotic treatments. Preclinical studies suggest that QCC-374 could enhance the effectiveness of existing antibiotics and reduce the development of resistance.